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Symbol
Name
ID

Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Eosinophilia

Increased T cell count

Leukopenia

Keratoconjunctivitis sicca

Pericarditis

Abnormal lymph node morphology

Lymphadenopathy

Abnormality of the spleen

Uveitis

Iridocyclitis

Epididymitis

Lupus nephritis

Nephritis

Abnormality of the immune system

Erythema nodosum

Discoid lupus rash

Maculopapular exanthema

Malar rash

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Autoimmunity

Anti-citrullinated protein antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Rheumatoid factor positive

Systemic lupus erythematosus

Disease(s) Associated with SLC11A1

Behcet's disease

leprosy

rheumatoid arthritis

sarcoidosis

systemic lupus erythematosus

type 1 diabetes mellitus

Mouse Phenotypes		enlarged spleen	increased neutrophil cell number	decreased lymphocyte cell number	abnormal spleen morphology	abnormal susceptibility to bacterial infection	decreased susceptibility to bacterial infection	increased susceptibility to bacterial infection
Availability	Mouse Genotype	enlarged spleen	increased neutrophil cell number	decreased lymphocyte cell number	abnormal spleen morphology	abnormal susceptibility to bacterial infection	decreased susceptibility to bacterial infection	increased susceptibility to bacterial infection
	Slc11a1^em1(IMPC)Mbp/Slc11a1^em1(IMPC)Mbp
	Slc11a1^r/Slc11a1^r
	Slc11a1^s/Slc11a1^s
	Slc11a1^tm1Mcg/Slc11a1^tm1Mcg
	Slc11a1^r/Slc11a1^s
	Slc11a1^s/Slc11a1^r
	Slc11a1^tm1Mcg/Slc11a1^s

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23